Understanding microRNAs in neurodegeneration
Identifieur interne : 002159 ( Main/Corpus ); précédent : 002158; suivant : 002160Understanding microRNAs in neurodegeneration
Auteurs : Stephen M. Eacker ; Ted M. Dawson ; Valina L. DawsonSource :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2009-12.
Abstract
Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.
Url:
DOI: 10.1038/nrn2726
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His laboratory is interested in understanding the underlying mechanisms of neuron death and Parkinson's disease through the study of familial associated mutations.</note><affiliation>Ted M. Dawson received his undergraduate training from Montana State University, Bozeman, USA, his medical and pharmacology training at the University of Utah in Salt Lake City, USA, and his neurology training at Hospital of the University of Pennsylvania, Philadelphia, USA. Presently he is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases, Co-director of the Neuroregeneration and Stem Cell Programs in the Institute for Cell Engineering and Director of the Parkinson's Disease and Movement Disorder Center at the Johns Hopkins University School of Medicine. His laboratory is interested in understanding the underlying mechanisms of neuron death and Parkinson's disease through the study of familial associated mutations.</affiliation><affiliation>Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the Neuroregeneration and Stem Cell Programs, the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.</affiliation><affiliation>Ted M. Dawson and Valina L. Dawson are also at the Department of Neuroscience at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.</affiliation></author><author><persName><forename type="first">Valina L.</forename><surname>Dawson</surname></persName><email>vdawson@jhmi.edu</email><note type="biography">Valina L. Dawson received her B.S. in environmental toxicology at the University of California at Davis, USA, and her Ph.D. in pharmacology and toxicology at the University of Utah. Her postdoctoral training was conducted at the University of Pennsylvania, Philadelphia, USA, and the National Institute on Drug Abuse. She joined the Johns Hopkins University School of Medicine in 1994, where she is now Professor in Neurology, Neuroscience and Physiology and Co-director of the Neuroregeneration and Stem Cell Programs in the Institute for Cell Engineering. Her laboratory studies the cellular signalling events that underlie neuronal cell death and neuronal survival in models of Parkinson's disease and stroke.</note><affiliation>Valina L. Dawson received her B.S. in environmental toxicology at the University of California at Davis, USA, and her Ph.D. in pharmacology and toxicology at the University of Utah. Her postdoctoral training was conducted at the University of Pennsylvania, Philadelphia, USA, and the National Institute on Drug Abuse. She joined the Johns Hopkins University School of Medicine in 1994, where she is now Professor in Neurology, Neuroscience and Physiology and Co-director of the Neuroregeneration and Stem Cell Programs in the Institute for Cell Engineering. 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Her laboratory studies the cellular signalling events that underlie neuronal cell death and neuronal survival in models of Parkinson's disease and stroke.</p></bio></cau><aff><oid id="a1"></oid>Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the <org>Neuroregeneration and Stem Cell Programs, the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine</org>, <cty>Baltimore</cty>, <st>Maryland</st> <zip>21205</zip>, <cny>USA</cny>.</aff><aff><oid id="a2"></oid>Ted M. Dawson and Valina L. Dawson are also at the <org>Department of Neuroscience at the Johns Hopkins University School of Medicine</org>, <cty>Baltimore</cty>, <st>Maryland</st> <zip>21205</zip>, <cny>USA</cny>.</aff><aff><oid id="a3"></oid>Valina L. Dawson is also at the <org>Department of Physiology at the Johns Hopkins University School of Medicine</org>, <cty>Baltimore</cty>, <st>Maryland</st> <zip>21205</zip>, <cny>USA</cny>.</aff><caff><coid id="c1"></coid><email>tdawson@jhmi.edu</email></caff><caff><coid id="c2"></coid><email>vdawson@jhmi.edu</email></caff></aug><hst><pubdate type="aop" year="2009" month="11" day="11"></pubdate></hst><websumm>Multiple roles for microRNA-mediated regulation of mRNA translation in the nervous system have emerged in recent years. Dawson and colleagues discuss the mechanisms by which microRNAs might influence neurodegenerative disease pathogenesis and outline key questions for future research.</websumm><abs><p>Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. 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Dawson are also at the Department of Neuroscience at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.</affiliation><affiliation>Valina L. Dawson is also at the Department of Physiology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.</affiliation><affiliation>E-mail: vdawson@jhmi.edu</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Valina L. Dawson received her B.S. in environmental toxicology at the University of California at Davis, USA, and her Ph.D. in pharmacology and toxicology at the University of Utah. Her postdoctoral training was conducted at the University of Pennsylvania, Philadelphia, USA, and the National Institute on Drug Abuse. She joined the Johns Hopkins University School of Medicine in 1994, where she is now Professor in Neurology, Neuroscience and Physiology and Co-director of the Neuroregeneration and Stem Cell Programs in the Institute for Cell Engineering. 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